circRNA basic information
circBase ID: -
Name: hsa_circ_ANKHD1
Synonym: circANKHD1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4006
DO name: bladder urothelial carcinoma
Disease details: bladder urothelial carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SV-HUC-1, T24, J82, TCC-SUP, UM-UC-3, SW-780, 5637, RT4
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: LRPPRC regulates cell proliferation and apoptosis in UCB cells_n vitro_nd_n vivo. LRPPRC regulates the expression of mitochondrial mRNAs and FOXM1 in UCB cells. LRPPRC regulates apoptosis via oxidative stress in UCB cells
Molecular mechanism: LRPPRC modulates ROS balance and protects UCB cells from oxidative stress via mt-mRNA metabolism and the circANKHD1/FOXM1 axis. In addition, the SRA stem-loop interacting RNA binding protein (SLIRP) directly interacted with LRPPRC to protect it from ubiquitination and proteasomal degradation. Notably, we showed that LRPPRC modulated the tumorigenesis of UCB cells in a circANKHD1-FOXM1-dependent manner.
Survival: poor
Supported No.:
 1
Description:

LRPPRC exerts critical roles in regulating UCB redox homeostasis and tumorigenesis, and is a prognostic factor for UCB; suggesting that LRPPRC may serve as an exploitable therapeutic target in UCB.
Other information
Title:

LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.

Journal: Redox Biol
Published: 2021/12/6
PubMed ID: 34864630