circRNA basic information
circBase ID: -
Name: hsa_circ_LMP2A
Synonym: ebv-circLMP2A
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3717
DO name: gastric adenocarcinoma
Disease details: EBV-associated gastric carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: EBVaGC cell line (NU719, AGS)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: The expression of ebv-circLMP2A was positively correlated with MVD, HIF1alpha, and VEGFA expression in clinical samples of EBVaGC. Knockdown of ebv-circLMP2A repressed tube formation and migration of HUVECs and decreased VEGFA and HIF1alpha expression in cancer cells under hypoxia, while ectopic expression of ebv-circLMP2A reversed these effects.
Molecular mechanism: knockdown of HIF1alpha blocked the upregulation of ebv-circLMP2A by hypoxia, and ebv-circLMP2A interacted with KHSRP to enhance KHSRP-mediated decay of VHL mRNA, leading to the accumulation of HIF1alpha under hypoxia. There was a positive feedback loop between HIF1alpha and ebv-circLMP2A that promotes angiogenesis under hypoxia.
Survival: -
Supported No.:
 1
Description:

Ebv-circLMP2A was essential in regulating tumor angiogenesis in EBVaGC and might provide a valuable therapeutic target for EBVaGC.
Other information
Title:

Hypoxia-induced ebv-circLMP2A promotes angiogenesis in EBV-associated gastric carcinoma through the KHSRP/VHL/HIF1alpha/VEGFA pathway.

Journal: Cancer Lett
Published: 2021/12/6
PubMed ID: 34863886