circRNA basic information
circBase ID: -
Name: hsa_circ_AXIN1
Synonym: circAXIN1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: AGS, MKN28, GES-1, BGC-823, SGC7901, NCI-N87
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: CircAXIN1 is highly expressed in GC tissues compared with its expression in paired adjacent normal gastric tissues. CircAXIN1 encodes a 295 amino acid (aa) novel protein, which was named AXIN1-295aa. CircAXIN1 overexpression enhances the cell proliferation, migration, and invasion of GC cells, while the knockdown of circAXIN1 inhibits the malignant behaviors of GC cells in vitro and in vivo.
Molecular mechanism: AXIN1-295aa competitively interacts with APC, leading to dysfunction of the ˇ°destruction complexˇ± of the Wnt pathway. Released beta-catenin translocates to the nucleus and binds to the TCF consensus site on the promoter, inducing downstream gene expression.
Survival: poor
Supported No.:
 1
Description:

CircAXIN1 encodes a novel protein, AXIN1-295aa. AXIN1-295aa functions as an oncogenic protein, activating the Wnt signaling pathway to promote GC tumorigenesis and progression, suggesting a potential therapeutic target for GC.
Other information
Title:

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/beta-catenin signaling pathway to promote gastric cancer progression.

Journal: Mol Cancer
Published: 2021/12/6
PubMed ID: 34863211