circRNA basic information
circBase ID: -
Name: hsa_circ_SETD3
Synonym: Circ_SETD3
Host Gene: hsa-miR-873-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell-lines (PC9, HCC827)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-873-5p
Biological function: Reduced expression of circ_SETD3 repressed gefitinib resistance, proliferation, migration and invasion, but induced apoptosis of gefitinib-resistant NSCLC cells
Molecular mechanism: circ_SETD3 modulated gefitinib sensitivity and tumor development by binding to hsa-miR-873-5p. APPBP2 upregulation attenuated hsa-miR-873-5p-mediated gefitinib sensitivity and NSCLC progression. Furthermore, circ_SETD3 absence improved tumor sensitivity to gefitinib_n vivo.
Survival: -
Supported No.:
 3
Description:

Circ_SETD3 knockdown improved gefitinib sensitivity and repressed NSCLC cell malignancy via miR-873-5p/APPBP2 axis, which provides a theoretical basis for using circ_SETD3-based therapeutic strategies to improve NSCLC sensitivity to gefitinib.
Other information
Title:

Circ_SETD3 regulates gefitinib sensitivity and tumor progression by miR-873-5p-dependent regulation of APPBP2 in non-small cell lung cancer.

Journal: J Chemother
Published: 2021/12/5
PubMed ID: 34861803