circRNA basic information
circBase ID: -
Name: hsa_circ_FBXW7
Synonym: circFBXW7
Host Gene: hsa-miR-216a-3p
 
 
 
Disease basic information
DO ID:
 7148
DO name: rheumatoid arthritis
Disease details: rheumatoid arthritis
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human synovial cell line (MH7A), human bone marrow-derived MSCs
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DS
Associated gene: -
Associated microRNA: hsa-miR-216a-3p
Biological function: Exosomal circFBXW7 treatment suppressed proliferation, migration and inflammatory response of RA-FLSs and damage of RA model.
Molecular mechanism: CircFBXW7 could directly sponge hsa-miR-216a-3p to upregulate the expression of HDAC4. Inhibition of HDAC4 or upregulation of hsa-miR-216a-3p abolished the therapeutic function of exosomal circFBXW7. Our data demonstrated that circFBXW7 and HDAC4 were decreased, and hsa-miR-216a-3p was elevated in clinical RA sample compared with healthy samples.
Survival: -
Supported No.:
 1
Description:

MSC-derived exosomal circFBXW7 suppressed proliferation, migration and inflammatory response of RA-FLSs and damage of RA rats via sponging miR-216a-3p and release the activation of HDAC4. These findings may provide a novel therapeutic target for RA.
Other information
Title:

Mesenchymal Stem Cell-Originated Exosomal Circular RNA circFBXW7 Attenuates Cell Proliferation, Migration and Inflammation of Fibroblast-Like Synoviocytes by Targeting miR-216a-3p/HDAC4 in Rheumatoid Arthritis.

Journal: J Inflamm Res
Published: 2021/12/3
PubMed ID: 34853524