circRNA basic information
circBase ID: -
Name: hsa_circ_EAF2
Synonym: CircEAF2
Host Gene: hsa-miR-BART19-3p
 
 
 
Disease basic information
DO ID:
 707
DO name: B-cell lymphoma
Disease details: B-cell lymphoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human B-lymphoma cell lines (Farage, SU-DHL-4, OCI-LY-10, OCI-LY-7, Toledo), EBV-producing marmoset B-cell line (B95-8)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: APC, beta-catenin
Associated microRNA: hsa-miR-BART19-3p
Biological function: In EBV-positive B lymphoma cells, circEAF2 overexpression induced lymphoma cell apoptosis and sensitized lymphoma cells to epirubicin.
Molecular mechanism: circEAF2 specifically targeted EBV-encoded hsa-miR-BART19-3p, upregulated APC, and suppressed downstream beta-catenin expression, resulting in inactivation of Wnt signaling pathway and inhibition of EBV + DLBCL cell proliferation. In EBV-positive B-lymphoma murine models, xenografted tumors with circEAF2 overexpression presented decreased Ki-67 positivity, increased cell apoptosis and retarded tumor growth.
Survival: better
Supported No.:
 1
Description:

CircEAF2 counteracted EBV + DLBCL progression via miR-BART19-3p/APC/beta-catenin axis, referring circEAF2 as a potential prognostic biomarker. Therapeutic targeting EBV-encoded miRNA may be a promising strategy in treating EBV-associated lymphoid malignancies.
Other information
Title:

CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/beta-catenin axis.

Journal: Mol Cancer
Published: 2021/12/3
PubMed ID: 34852843