circRNA basic information
circBase ID: -
Name: hsa_circ_FLNA
Synonym: circFLNA
Host Gene: hsa-miR-216a-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BCa cell lines (EJ, T24, 5637, TCC-SUP), human normal bladder epithelial cells (SV-HUC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: BTG2
Associated microRNA: hsa-miR-216a-3p
Biological function: Inhibition of malignant development of bladder carcinoma cells by circFLNA,CircFLNA inhibits the stemness of bladder carcinoma cells
Molecular mechanism: hsa-miR-216a-3p_as a target gene of circFLNA and could target BTG2. Further analysis finally demonstrated that circFLNA sponged hsa-miR-216a-3p and indirectly promoted BTG2 expression, ultimately regulating proliferation, migration, invasion and EMT of BCa cells.
Survival: -
Supported No.:
 2
Description:

In conclusion, circFLNA inhibits the malignant phenotype of BCa cells and their stemness through miR-216a-3p/BTG2, thus suppressing BCa progression.
Other information
Title:

Circular RNA circFLNA inhibits the development of bladder carcinoma through microRNA miR-216a-3p/BTG2 axis.

Journal: Bioengineered
Published: 2021/12/3
PubMed ID: 34852712