circRNA basic information
circBase ID: hsa_circ_0005797
Name: hsa_circ_ATP2C1
Synonym: -
Host Gene: hsa-miR-298
 
 
 
Disease basic information
DO ID:
 1380
DO name: endometrial cancer
Disease details: endometrial cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: EC cell lines (HEC-1-B, AN3-CA, KLE, HEC1-A, Ishikawa), human endometrial endothelial cells (HEEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-298
Biological function: In the present study, we found that hsa_circ_0005797 expression was significantly increased in EC biological samples and cell lines, whereas its downregulation inhibited_n vitro_umor cells proliferation and invasion phenotypes and suppressed tumor formation in nude mice.
Molecular mechanism: In mechanism, we characterized hsa_circ_0005797 as an hsa-miR-298 sponge, with CTNND1 identified as a target of hsa-miR-298. Our rescue assay data further revealed that hsa_circ_0005797 silencing inhibited EC cells proliferation and invasion via hsa-miR-298/CTNND1 signaling.
Survival: -
Supported No.:
 1
Description:

In conclusion, our study confirmed hsa_circ_0005797 is a poor prognostic factor for EC and modulates EC phenotypes by regulating the hsa_circ_000579/miR-298/CTNND1 signaling, which provides potential treatment targets for EC.
Other information
Title:

Downregulated circular RNA hsa_circ_0005797 inhibits endometrial cancer by modulating microRNA-298/Catenin delta 1 signaling.

Journal: Bioengineered
Published: 2021/12/3
PubMed ID: 34852711