circRNA basic information
circBase ID: -
Name: hsa_circ_Smg5
Synonym: CircSmg5
Host Gene: hsa-miR-194-5p
 
 
 
Disease basic information
DO ID:
 0080001
DO name: bone disease
Disease details: bone disease
Species: human
Species details: human
Sample type: cell line
Sample type details: bone marrow mesenchymal stem cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-194-5p
Biological function: CircSmg5 is in stable circular structure. CircSmg5 expression was elevated in the process of BMSC osteogenic differentiation. CircSmg5 overexpression promoted the osteogenic differentiation of BMSCs.
Molecular mechanism: circSmg5 bound with hsa-miR-194-5p, whose expression was decreased in the osteogenic differentiation of BMSCs. hsa-miR-194-5p directly targeted the 3UTR of Fzd6. The mRNA and protein levels of Fzd6 were positively modulated by circSmg5 and negatively regulated by hsa-miR-194-5p in BMSCs.
Survival: -
Supported No.:
 1
Description:

circSmg5 was demonstrated to promote the BMSC osteogenic differentiation by targeting the miR-194-5p/Fzd6 axis to activate the Wnt/beta-catenin signaling.
Other information
Title:

CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR-194-5p/Fzd6 axis and beta-catenin signaling.

Journal: Environ Toxicol
Published: 2021/12/2
PubMed ID: 34850997