circRNA basic information
circBase ID: -
Name: hsa_circ_AKT3
Synonym: CircAKT3
Host Gene: hsa-miR-515-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MKN-7, HGC-27
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-515-5p
Biological function: The expression of circAKT3 in GC tissues and cells was enhanced. The knockdown of circAKT3 inhibited GC cell proliferation, survival and glutamine metabolism, as well as tumor growth in animal models.
Molecular mechanism: hsa-miR-515-5p was a target of circAKT3, and hsa-miR-515-5p suppressed the expression of SLC1A5 by binding to SLC1A5 3UTR. CircAKT3 relieved the inhibition of hsa-miR-515-5p on SLC1A5 expression by targeting hsa-miR-515-5p. The effects of circAKT3 knockdown were reversed by hsa-miR-515-5p depletion, and the effects of hsa-miR-515-5p restoration were abolished by SLC1A5 overexpression.
Survival: poor
Supported No.:
 4
Description:

CircAKT3 promotes the malignant development of GC by activating SLC1A5 expression via targeting miR-515-5p.
Other information
Title:

CircAKT3 promotes cell proliferation, survival and glutamine metabolism of gastric cancer by activating SLC1A5 expression via targeting miR-515-5p.

Journal: Histol Histopathol
Published: 2021/12/2
PubMed ID: 34850965