circRNA basic information
circBase ID: hsa_circ_0008037
Name: -
Synonym: circ_0008037
Host Gene: hsa-miR-433-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: A549 cells (CL_0016, Procell), H1975 cells (CL_0298, Procell), as well as human bronchial epithelial cells BEAS_2B (CL_0496, Procell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-433-3p
Biological function: Circ_0008037 downregulation reduced tumor growth in vivo and repressed proliferation, migration, invasion, and decreased the Warburg effect of NSCLC cells in vitro.
Molecular mechanism: circ_0008037 regulated nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1) expression via sponging hsa-miR-433-3p. Furthermore, hsa-miR-433-3p inhibitor reversed the inhibiting influence of circ_0008037 silencing on proliferation, migration, invasion, and the Warburg effect of NSCLC cells. Also, NUCKS1 elevation overturned the repressive influence of hsa-miR-433-3p mimic on proliferation, migration, invasion, and the Warburg effect of NSCLC cells.
Survival: poor
Supported No.:
 1
Description:

Circ_0008037 accelerated tumor growth and elevated the Warburg effect via regulating NUCKS1 expression by adsorbing miR-433-3p, providing an underlying target for NSCLC treatment.
Other information
Title:

CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer.

Journal: Thorac Cancer
Published: 2021/12/2
PubMed ID: 34850570