circRNA basic information
circBase ID: -
Name: hsa_circ_UTRN
Synonym: Circ_UTRN
Host Gene: hsa-miR-320-3p
 
 
 
Disease basic information
DO ID:
 2913
DO name: acute pancreatitis
Disease details: acute pancreatitis
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: pancreatic acinar cell line (AR42J)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-320-3p
Biological function: The expression of circ_UTRN was decreased by caerulein in pancreatic acinar cells, ectopic overexpression of circ_UTRN reduced inflammation and promoted apoptosis in caerulein-mediated pancreatic acinar cells
Molecular mechanism: circ_UTRN served as a sponge of hsa-miR-320-3p, and hsa-miR-320-3p directly targeted PTK2. Rescue assay suggested that the promotion of apoptosis and inhibition of inflammation induced by circ_UTRN re-expression in caerulein-mediated pancreatic acinar cells were partially abolished by hsa-miR-320-3p overexpression or PTK2 knockdown. Besides that, hsa-miR-320-3p inhibition impaired caerulein-induced cell apoptosis arrest and inflammation via targeting PTK2.
Survival: -
Supported No.:
 1
Description:

Up-regulation of circ_UTRN in pancreatic acinar cells attenuates caerulein-evoked cell apoptosis arrest and inflammation enhancement via miR-320-3p/PTK2, suggesting that circ_UTRN/miR-320-3p/PTK2 axis might be engaged in caerulein-induced AP.
Other information
Title:

Circ_UTRN ameliorates caerulein-induced acute pancreatitis in vitro via reducing inflammation and promoting apoptosis through miR-320-3p/PTK2 axis.

Journal: J Pharm Pharmacol
Published: 2021/12/2
PubMed ID: 34850057