| Detected method: |
Q
|
| Detected method confidence |
High
|
| Expression pattern: |
|
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-383-5p |
| Biological function: |
CircCRIM1 and CRIM1 had higher expression in ovarian cancer than in normal ovarian tissues, and both of them promoted ovarian cancer progression in vitro. In vivo circCRIM1 promoted the growth of tumors. CircCRIM1 and CRIM1 had a positive correlation relationship in the same cohort of ovarian cancer tissues. |
| Molecular mechanism: |
Bioinformatics predicted and dual luciferase assay confirmed circCRIM1 and CRIM1 bond with hsa-miR-145-5p, and circCRIM1 bond with hsa-miR-383-5p additionally. CircCRIM1 positively affected the expression of CRIM1. After circCRIM1 was over-expressed, hsa-miR-145-5p mimics transfection reversed the expression of CRIM1. Western blot discovered circCRIM1 positively affected the expression of zinc finger E-box binding homeobox 2 (ZEB2). Rescue experiments found hsa-miR-383-5p mimics reversed ZEB2 expression and the cancer-promoting effects of circCRIM1. |
| Survival: |
- |
Supported
No.: |
1 |
| Description: |
CircCRIM1 bond with miR-145-5p to work as competing endogenous RNA (ceRNA) of CRIM1, and circCRIM1 bond with miR-383-5p to improve the expression of ZEB2 in ovarian cancer. CircCRIM1 and CRIM1 promoted the ovarian cancer progression and supplied a novel insight into the researches of ovarian cancer. |