circRNA basic information
circBase ID: hsa_circ_0008726
Name: hsa_circ_DNAJB6
Synonym: circ_0008726
Host Gene: hsa-miR-345-3p
 
 
 
Disease basic information
DO ID:
 10591
DO name: pre-eclampsia
Disease details: preeclampsia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HTR-8/SVneo cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-345-3p
Biological function: Silencing circ_0008726 promoted cell migration and EMT (epithelial-mesenchymal transition), while circ_0008726 overexpression suppressed these processes.
Molecular mechanism: circ_0008726 sponged hsa-miR-345-3p to negatively regulate its expression, and hsa-miR-345-3p negatively modulated the expression of RYBP. In PE samples, the expression level of circ_0008726 was negatively correlated with hsa-miR-345-3p level, but was positively correlated with RYBP expression. Transfection of hsa-miR-345-3p mimic or RYBP knockdown counteracted the effects of circ_0008726 overexpression on cell migration and EMT.
Survival: -
Supported No.:
 1
Description:

Our data demonstrate the upregulation of circ_0008726 in PE placenta, which inhibits the migration, invasion, and EMT of HTR-8/SVneo cells by targeting miR-345-3p/RYBP axis. These data suggest that circ_0008726 could be a potential biomarker and therapeutic target for PE.
Other information
Title:

Upregulation of circRNA hsa_circ_0008726 in Pre-eclampsia Inhibits Trophoblast Migration, Invasion, and EMT by Regulating miR-345-3p/RYBP Axis.

Journal: Reprod Sci
Published: 2021/12/1
PubMed ID: 34845670