circRNA basic information
circBase ID: -
Name: hsa_circ_ATXN7
Synonym: CircATXN7
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal breast epithelial cells (MCF10A), breast cancer cells (MCF7, T47D, MDA-MB-231, MDA-MB-468, BT549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-149-5p
Biological function: circATXN7 and HOXA11 levels were enhanced, whereas miR-149-5p level was declined in breast cancer tissues and cells. CircATXN7 silencing suppressed breast cancer development and doxorubicin resistance.
Molecular mechanism: circATXN7 upregulated HOXA11 via absorbing hsa-miR-149-5p, thereby inducing breast cancer cell progression and reducing doxorubicin sensitivity. Besides, depletion of circATXN7 enhanced doxorubicin sensitivity in vivo. Interference of circATXN7 inhibited breast cancer progression and doxorubicin resistance via mediating hsa-miR-149-5p/HOXA11 axis
Survival: -
Supported No.:
 1
Description:

Interference of circATXN7 inhibited breast cancer progression and doxorubicin resistance via mediating miR-149-5p/HOXA11 axis, which might provide a possible biomarker for breast cancer therapy.
Other information
Title:

CircATXN7 contributes to the progression and doxorubicin resistance of breast cancer via modulating miR-149-5p/HOXA11 pathway.

Journal: Anticancer Drugs
Published: 2021/12/1
PubMed ID: 34845164