circRNA basic information
circBase ID: hsa_circ_0005033
Name: -
Synonym: Circ_0005033
Host Gene: hsa-miR-107
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human bronchial epithelial cell (NHBEC), LSCC cells Tu 177, FD-LSC-1, Tu 686
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-107
Biological function: Silencing circ_0005033 facilitated apoptosis rate and lowered cell viability, proliferation, migration and invasion of LSCC cells, as well as delayed xenograft tumor growth.
Molecular mechanism: circ_0005033 and IGF1R were competing endogenous RNAs for hsa-miR-107 via target binding.
Survival: -
Supported No.:
 1
Description:

Circ_0005033 was oncogenic in LSCC by regulating cell progression and Cisplatin sensitivity at least via miR-107/IGF1R axis.
Other information
Title:

Circ_0005033 is an oncogene in laryngeal squamous cell carcinoma and regulates cell progression and Cisplatin sensitivity via miR-107/IGF1R axis.

Journal: Anticancer Drugs
Published: 2021/12/1
PubMed ID: 34845162