circRNA basic information
circBase ID: hsa_circ_0016760
Name: -
Synonym: circ_0016760
Host Gene: hsa-miR-29b
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human lung epithelial cell-line (BEAS-2B), NSCLC cell lines (A549, H1299), human umbilical vein endothelial cells (HUVEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HIF1A
Associated microRNA: hsa-miR-29b
Biological function: PESV treatment downregulated circ_0016760 expression. Circ_0016760 silencing or PESV treatment repressed cell migration, invasion, proliferation and tube formation under hypoxia in NSCLC cells. Circ_0016760 overexpression restored the effects of PESV treatment on NSCLC process under hypoxia.
Molecular mechanism: circ_0016760 acted as a sponge of hsa-miR-29b, and hsa-miR-29b bound to HIF1A. Meanwhile, hsa-miR-29b inhibitor impaired the influences of circ_0016760 knockdown on NSCLC process under hypoxia. Further, ectopic circ_0016760 expression restrained the effects of PESV exposure on tumor formation in vivo.
Survival: -
Supported No.:
 6
Description:

Circ_0016760 overexpression counteracted PESV-induced repression of NSCLC cell malignancy and angiogenesis under hypoxia through miR-29b/HIF1A axis.
Other information
Title:

PESV represses non-small cell lung cancer cell malignancy through circ_0016760 under hypoxia.

Journal: Cancer Cell Int
Published: 2021/11/29
PubMed ID: 34838012