circRNA basic information
circBase ID: -
Name: hsa_circ_MUC16
Synonym: Circ_MUC16
Host Gene: hsa-miR-1182
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Ovarian cancer cells (A2780, SK-OV-3), normal ovarian epithelial cells (IOSE-80)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: S100B
Associated microRNA: hsa-miR-1182
Biological function: Propofol inhibited ovarian cancer cell proliferation, glycolysis metabolism, migration and invasion, which were partly recovered by circ_MUC16 overexpression. Circ_MUC16 was downregulated in Propofol-treated ovarian cancer cells. Besides, circ_MUC16 knockdown enhanced the effects of Propofol to further inhibit tumor growth in vivo.
Molecular mechanism: hsa-miR-1182 was a target of circ_MUC16, and circ_MUC16 knockdown-inhibited cell proliferation, glycolysis metabolism, migration and invasion were partly restored by hsa-miR-1182 inhibition. In addition, S100B was a target of hsa-miR-1182, and hsa-miR-1182-suppressed cell proliferation, glycolysis metabolism, migration and invasion were partly restored by S100B overexpression.
Survival: -
Supported No.:
 1
Description:

Circ_MUC16 overexpression alleviated the effects of Propofol to promote the aggressive behaviors of ovarian cancer by targeting the miR-1182/S100B network.
Other information
Title:

Circ_MUC16 attenuates the effects of Propofol to promote the aggressive behaviors of ovarian cancer by mediating the miR-1182/S100B signaling pathway.

Journal: BMC Anesthesiol
Published: 2021/11/29
PubMed ID: 34837947