circRNA basic information
circBase ID: hsa_circ_0084443
Name: -
Synonym: Circ_0084443
Host Gene: hsa-miR-17-3p
 
 
 
Disease basic information
DO ID:
 37
DO name: skin disease
Disease details: skin wound healing
Species: human
Species details: human
Sample type: cell line
Sample type details: HaCaT, NHEK cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: FOXO4
Associated microRNA: hsa-miR-17-3p
Biological function: Circ_0084443 acted as a miR-17-3p sponge and circ_0084443 overexpression alleviated TGF-beta1-induced migration of keratinocytes by sponging miR-17-3p.
Molecular mechanism: FOXO4 was a target for hsa-miR-17-3p. The downregulation of hsa-miR-17-3p suppressed cell migration in TGF-beta1-induced cells by increasing the FOXO4 level. Circ_0084443 positively regulated the FOXO4 expression by sponging hsa-miR-17-3p. Circ_0084443 suppressed the TGFbeta signaling pathway by affecting the hsa-miR-17-3p/FOXO4 axis.
Survival: -
Supported No.:
 1
Description:

These results exhibited that circ_0084443 suppressed the TGF-beta1-induced keratinocyte migration by regulating the miR-17-3p/FOXO4 axis, suggesting the application potential of circ_0084443 in wound-healing-related diseases.
Other information
Title:

Circ_0084443 Inhibits Wound Healing Via Repressing Keratinocyte Migration Through Targeting the miR-17-3p/FOXO4 Axis.

Journal: Biochem Genet
Published: 2021/11/28
PubMed ID: 34837127