circRNA basic information
circBase ID: hsa_circ_0092367
Name: -
Synonym: Circ_0092367
Host Gene: hsa-miR-1206
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Four different PC cell lines (AsPC-1, BxPC-3, SW-1990, PaCa-2), a normal pancreatic epithelial cell line (HPDE6-C7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ESRP1
Associated microRNA: hsa-miR-1206
Biological function: Gain- and loss-of-function assays revealed that circ_0092367 inhibited epithelial-mesenchymal transition (EMT) phenotypes and sensitized PC cells to gemcitabine treatment in vitro and in vivo.
Molecular mechanism: Cytoplasmic circ_0092367 could directly repress the levels of hsa-miR-1206 and thus upregulate the expression of ESRP1, thereby inhibiting EMT and enhancing the sensitivity of PC cells to gemcitabine treatment.
Survival: better
Supported No.:
 1
Description:

Our findings show that circ_0092367 plays a crucial role in sensitizing PC cells to gemcitabine by modulating the miR-1206/ESRP1 axis, highlighting its potential as a valuable therapeutic target in PC patients.
Other information
Title:

Circ_0092367 Inhibits EMT and Gemcitabine Resistance in Pancreatic Cancer via Regulating the miR-1206/ESRP1 Axis.

Journal: Genes (Basel)
Published: 2021/11/28
PubMed ID: 34828307