circRNA basic information
circBase ID: -
Name: hsa_circ_SFMBT2
Synonym: Circ-SFMBT2
Host Gene: hsa-miR-582-3p
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: cell line
Sample type details: AML cell lines (U937, NB4, K562, HL-60), human bone marrow stromal cell line (HS-5)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZBTB20
Associated microRNA: hsa-miR-582-3p
Biological function: Circ-SFMBT2 and ZBTB20 levels were elevated, while miR-582-3p level was reduced in AML patients and cells. Depletion of circ-SFMBT2/ZBTB20 impeded proliferation, migration, invasion and glycolysis and induced apoptosis in AML cells.
Molecular mechanism: Moreover, circ-SFMBT2 facilitated AML progression by sponging hsa-miR-582-3p, and hsa-miR-582-3p targeted ZBTB20 to hinder AML development.
Survival: -
Supported No.:
 1
Description:

Knockdown of circ-SFMBT2 suppressed AML progression by regulating the miR-582-3p/ZBTB20 axis, which might provide a potential therapeutic strategy for AML.
Other information
Title:

Circ-SFMBT2 facilitates the malignant growth of acute myeloid leukemia cells by modulating miR-582-3p/ZBTB20 pathway.

Journal: Histol Histopathol
Published: 2021/11/27
PubMed ID: 34825699