circRNA basic information
circBase ID: hsa_circ_0023404
Name: -
Synonym: circ_0023404
Host Gene: hsa-miR-636
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human cervical epithelial cells (HcerEpic), cervical cancer cell lines (C33A, HeLa, SiHa)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CYP2S1
Associated microRNA: hsa-miR-636
Biological function: circ_0023404 knockdown repressed proliferation, migration, invasion, and promoted apoptosis of cervical cancer cells in vitro
Molecular mechanism: circ_0023404 could directly binding to hsa-miR-636, hsa-miR-636 upregulation could block the malignant behaviors of cervical cancer cells in vitro, circ_0023404 silencing could repress the malignant behaviors of cervical cancer cells by interacting with hsa-miR-636 in vitro, CYP2S1 is a direct target of hsa-miR-636
Survival: -
Supported No.:
 3
Description:

our findings are the first to reveal the regulatory role of circ_0023404/miR-636/CYP2S1 axis in the regulation of cervical cancer progression (Figure8), providing a new potential therapeutic target for cervical cancer.
Other information
Title:

Circular RNA circ_0023404 serves as a miR-636 sponge to promote malignant behaviors in cervical cancer cells through upregulation of CYP2S1.

Journal: Kaohsiung J Med Sci
Published: 2021/11/27
PubMed ID: 34825467