circRNA basic information
circBase ID: hsa_circ_0044556
Name: -
Synonym: Circ_0044556
Host Gene: hsa-miR-665
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCT116, SW480, colonic epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Diaphanous Homolog 1
Associated microRNA: hsa-miR-665
Biological function: Silencing circ_0044556 inhibited cell proliferation, cell cycle progression, migration, invasion, and epithelial-mesenchymal transition in CRC cells.
Molecular mechanism: Circ_0044556 could directly target hsa-miR-665 and the function of circ_0044556 was associated with the regulation of hsa-miR-665. In addition, Diaphanous Homolog 1 was a target gene for hsa-miR-665 and the anti-tumor role of hsa-miR-665 in colorectal cancer was dependent on the downregulation of Diaphanous Homolog 1. Diaphanous Homolog 1 level was regulated by circ_0044556 via sponging hsa-miR-665 in CRC cells. In vivo assay suggested that circ_0044556 promoted CRC tumor growth by regulating the hsa-miR-665 and Diaphanous Homolog 1 levels.
Survival: -
Supported No.:
 2
Description:

Our findings manifested that circ_0044556 functioned as an oncogenic circRNA in colorectal cancer by mediating the miR-665/Diaphanous Homolog 1 axis, elucidating the molecular mechanism of circ_0044556 in CRC progression.
Other information
Title:

Circ_0044556 Promotes the Progression of Colorectal Cancer via the miR-665-Dependent Expression Regulation of Diaphanous Homolog 1.

Journal: Dig Dis Sci
Published: 2021/11/26
PubMed ID: 34822025