circRNA basic information
circBase ID: -
Name: hsa_circ_MYOF
Synonym: CircMYOF
Host Gene: hsa-miR-4739
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PDA cell lines (MIA PaCa-2, Capan-2, SW1990, PANC-1, BxPC-3, HPAF-II), immortalized pancreatic cell line (hTERT-HPNE), human embryonic kidney cell line (HEK-293T)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-4739
Biological function: CircMYOF plays an oncogenic role in PDA in vitro and in vivo
Molecular mechanism: CircMYOF facilitates glycolysis via the PI3K/AKT pathway in PDA, CircMYOF works as a sponge to hsa-miR-4739, VEGFA is a direct target of circMYOF/hsa-miR-4739
Survival: -
Supported No.:
 1
Description:

In summary, we identified a novel oncogenic circRNA-circMYOF in PDA. We also highlight that targeting the circMYOF/miR-4739/VEGFA/PI3K/AKT axis may be a promising strategy for the treatment of PDA. In the future, it is worthy investigating the potential regulatory mechanism on circMYOF expression.
Other information
Title:

CircMYOF triggers progression and facilitates glycolysis via the VEGFA/PI3K/AKT axis by absorbing miR-4739 in pancreatic ductal adenocarcinoma.

Journal: Cell Death Discov
Published: 2021/11/24
PubMed ID: 34811346