circRNA basic information
circBase ID: hsa_circ_0043256
Name: hsa_circ_ACACA
Synonym: -
Host Gene: hsa-miR-1252
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: A549, NCI-H460 cell
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: ITCH
Associated microRNA: hsa-miR-1252
Biological function: inhibit cell proliferation and induce apoptosis
Molecular mechanism: hsa_circ_0043256 could work as a hsa-miR-1252 sponge, which could in turn directly target a vital negative regulator of Canonical Wnt signaling, Itchy E3 ubiquitin protein ligase (ITCH), as validated by dual-luciferase assay.
Survival: -
Supported No.:
 3
Description:

Hsa_circ_0043256 could inhibit cell proliferation and induce apoptosis, while hsa_circ_0043256 knock-down could promote cell proliferation and restrain apoptosis induced by Cinnamaldehyde (CA).
Other information
Title:

Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer.

Journal: Biochem Biophys Res Commun
Published: 2017/9/30
PubMed ID: 28958934