circRNA basic information
circBase ID: hsa_circ_0003204
Name: -
Synonym: circ_0003204
Host Gene: hsa-miR-491-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: cell line
Sample type details: human umbilical vein endothelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ICAM1
Associated microRNA: hsa-miR-491-5p
Biological function: Circ_0003204 knockdown inhibited ox-LDL-induced inflammation and cell apoptosis, and promoted ox-LDL-depleted cell viability and tube formation ability in HUVECs.
Molecular mechanism: MiR-491-5p was a target of circ_0003204, and miR-491-5p directly bound to ICAM1 3UTR.
Survival: -
Supported No.:
 7
Description:

Circ_0003204 knockdown protects HUVECs against ox-LDL-induced injuries by targeting the miR-491-5p-ICAM1 pathway, hinting that circ_0003204 inhibition might prevent AS development.
Other information
Title:

Circ_0003204 knockdown protects endothelial cells against oxidized low-density lipoprotein-induced injuries by targeting the miR-491-5p-ICAM1 pathway.

Journal: J Thromb Thrombolysis
Published: 2021/11/20
PubMed ID: 34797473