circRNA basic information
circBase ID: -
Name: hsa_circ_TGFBR2
Synonym: circ_TGFBR2
Host Gene: hsa-miR-29a
 
 
 
Disease basic information
DO ID:
 0080685
DO name: aortic dissection
Disease details: aortic dissection
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: N-VSMCs, AD-VSMCs were obtained from normal aorta tissues, AD tissues
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: KLF4
Associated microRNA: hsa-miR-29a
Biological function: Inhibition of circ_TGFBR2 Promoted the Proliferation, Migration and Phenotype Switch in N-VSMCs Cells. Overexpression of circ_TGFBR2 Inhibited the Proliferation, Migration, and Phenotype Switch of AD-VSMCs Cells
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

In conclusion, our findings revealed that circ_TGFBR2 was down-regulated in AD on vivo and vitro level. Mechanistically, circ_TGFBR2 sponged miR-29a in AD-VSMC cells to regulate proliferation, migration and VSMCs phenotypic switch by affecting expression of target KLF4.
Other information
Title:

circ_TGFBR2 Inhibits Vascular Smooth Muscle Cells Phenotypic Switch and Suppresses Aortic Dissection Progression by Sponging miR-29a.

Journal: J Inflamm Res
Published: 2021/11/20
PubMed ID: 34795497