circRNA basic information
circBase ID: hsa_circ_0068515
Name: hsa_circ_TP63
Synonym: CircTP63
Host Gene: hsa-miR-217EZH2
 
 
 
Disease basic information
DO ID:
 3121
DO name: gallbladder cancer
Disease details: gallbladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human GBC cell lines (NOZ, GBC-SD, SGC-996), normal human intrahepatic biliary epithelial cell line (HIBEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-217EZH2
Biological function: CircTP63 downregulation inhibited the GBC cells proliferation and metastasis. Moreover, we found that circTP63 knockdown inhibited EZH2 expression by sponging to miR-217.
Molecular mechanism: -
Survival: poor
Supported No.:
 1
Description:

Our findings demonstrated that circTP63 sponged to miR-217 and regulated EZH2 expression and finally facilitated tumor progression in GBC..
Other information
Title:

CircTP63 promotes cell proliferation and invasion by regulating EZH2 via sponging miR-217 in gallbladder cancer.

Journal: Cancer Cell Int
Published: 2021/11/19
PubMed ID: 34789260