circRNA basic information
circBase ID: -
Name: mmu_circ_FOXO3
Synonym: circFOXO3
Host Gene: mmu-miR-214-3p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: cigarette smoke-induced lung injury
Species: mouse
Species details: mouse
Sample type: cell line, PDX
Sample type details: MLE12 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IKK-beta
Associated microRNA: mmu-miR-214-3p
Biological function: The knockdown of circFOXO3 suppresses inflammation in CS-exposed lungs in vivo.
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

Collectively, these findings reveal a crucial function of circFOXO3 in the pathological remodeling related to CS-induced inflammatory processes. Hence, circFOXO3 might be a good target for the treatment of inflammatory disorders similar to CS-induced lung inflammation.
Other information
Title:

Knockdown of circFOXO3 ameliorates cigarette smoke-induced lung injury in mice.

Journal: Respir Res
Published: 2021/11/19
PubMed ID: 34789242