circRNA basic information
circBase ID: -
Name: hsa_circ_CELF1
Synonym: circ_CELF1
Host Gene: hsa-miR-491-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human cell lines (A549, H1975), mouse Lewis lung cancer cell lines (LAA795)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EGFR
Associated microRNA: hsa-miR-491-5p
Biological function: Enforced expression of circ_CELF1 drives tumor progression_n vitro
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

Our data demonstrate that upregulation of circ_CELF1 elicits both oncogenic and immunoregulatory effects on the development of NSCLC. We believe that circ_CELF1 can act as a potential therapeutic target for the treatment of NSCLC.
Other information
Title:

Circular RNA CELF1 drives immunosuppression and anti-PD1 therapy resistance in non-small cell lung cancer via the miR-491-5p/EGFR axis.

Journal: Aging (Albany NY)
Published: 2021/11/18
PubMed ID: 34788230