circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1as
Synonym: Circ-CDR1as
Host Gene: hsa-miR-28-3p
 
 
 
Disease basic information
DO ID:
 2316
DO name: brain ischemia
Disease details: cerebral ischemia/reperfusion injury
Species: human
Species details: human
Sample type: cell line
Sample type details: mouse hippocampal neuronal cells (HT-22)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: TRAF3
Associated microRNA: hsa-miR-28-3p
Biological function: Circ-CDR1as is down-regulated after DEX treatment and reverses the effects of DEX on H/R-treated HT-22 cell proliferation, apoptosis, and inflammation
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

This work demonstrated that DEX exerted neuroprotective effects against H/R-induced HT-22 cell dysfunction through regulating the circ-CDR1as/miR-28-3p/TRAF3 cascade..
Other information
Title:

Circular RNA cerebellar degeneration-related protein 1 antisense RNA (Circ-CDR1as) downregulation induced by dexmedetomidine treatment protects hippocampal neurons against hypoxia/reoxygenation injury through the microRNA-28-3p (miR-28-3p)/tumor necrosis factor receptor-associated factor-3 (TRAF3) axis.

Journal: Bioengineered
Published: 2021/11/18
PubMed ID: 34787053