circRNA basic information
circBase ID: -
Name: hsa_circ_FURIN
Synonym: circ-FURIN
Host Gene: hsa-miR-195-5p
 
 
 
Disease basic information
DO ID:
 11612
DO name: polycystic ovary syndrome
Disease details: polycystic ovary syndrome
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: KGN, COV434, IOSE80 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BCL2
Associated microRNA: hsa-miR-195-5p
Biological function: Knockdown of circ-FURIN suppressed cell proliferation and facilitated apoptosis of KGN cells
Molecular mechanism: -
Survival: -
Supported No.:
 2
Description:

Circ-FURIN was upregulated in PCOS and GCs. Loss of circ-FURIN suppressed cell proliferation and facilitated apoptosis of KGN cells. The mechanism is associated with the miR-195-5p/BCL2 axis.
Other information
Title:

Knockdown of circ-FURIN suppresses the proliferation and induces apoptosis of granular cells in polycystic ovary syndrome via miR-195-5p/BCL2 axis.

Journal: J Ovarian Res
Published: 2021/11/18
PubMed ID: 34784951