circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 848
DO name: arthritis
Disease details: arthritis
Species: human
Species details: human
Sample type: cell line
Sample type details: human dermal microvascular endothelial cell (HDMEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXO1
Associated microRNA: hsa-miR-149-5p
Biological function: VEGF content in the supernatants of a RA-FLS and human dermal microvascular endothelial cell (HDMEC) co-culture as well as in RA-FLS co-cultured was significantly elevated in accordance with circHIPK3 levels. This increased VEGF expression may significantly upregulate endothelial tube formation and transwell migration, as well as microvessel sprouting in the_x vivo_ortic ring assay.
Molecular mechanism: CircHIPK3 was further illustrated to be a sponge for the forkhead box transcription factor O1 (FOXO1)-targeting miR-149-5p, leading to the changing expression of the downstream VEGF.
Survival: -
Supported No.:
 1
Description:

Thus, we elucidate a previously unknown mechanism between circRNAs and RA, and ATO has a significant protective effect on RA-FLS and CIA synovium_ia_ts inhibition of the angiogenic functional module of circHIPK3/miR-149-5p/FOXO1/VEGF, suggesting great potential for the combination therapy of ATO with circHIPK3 silencing.
Other information
Title:

Angiogenesis is Inhibited by Arsenic Trioxide Through Downregulation of the CircHIPK3/miR-149-5p/FOXO1/VEGF Functional Module in Rheumatoid Arthritis.

Journal: Front Pharmacol
Published: 2021/11/16
PubMed ID: 34776969