circRNA basic information
circBase ID: hsa_circ_0000745
Name: -
Synonym: circ_0000745
Host Gene: hsa-miR-3187-3p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ERBB4/PI3K/AKT
Associated microRNA: hsa-miR-3187-3p
Biological function: Downregulation of circ_0000745 reduced proliferation, aggressiveness, epithelial-mesenchymal transition, and stemness of SK-OV-3 cells, but this reduction was blocked upon miR-3187-3p inhibition or ERBB4 upregulation.
Molecular mechanism: through a hsa-miR-3187-3p/ERBB4/PI3K/AKT axis
Survival: -
Supported No.:
 1
Description:

circ_0000745 upregulated by IGF2BP2 promotes aggressiveness and stemness of OC cells through a miR-3187-3p/ERBB4/PI3K/AKT axis.
Other information
Title:

RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis.

Journal: J Ovarian Res
Published: 2021/11/15
PubMed ID: 34774079