circRNA basic information
circBase ID: hsa_circ_0057583
Name: -
Synonym: circ_0057583
Host Gene: hsa-miR-204-5p
 
 
 
Disease basic information
DO ID:
 178
DO name: vascular disease
Disease details: vascular endothelial injury
Species: human
Species details: human
Sample type: cell line
Sample type details: hBMECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NR4A1
Associated microRNA: hsa-miR-204-5p
Biological function: Downregulation of circ_0057583 abated LPS-induced hBMEC injury by inducing cell proliferation and angiogenesis, as well as inhibiting cell apoptosis, autophagy and inflammation.
Molecular mechanism: circ_0057583 sponged miR-204-5p to up-regulate NR4A1 level.
Survival: -
Supported No.:
 1
Description:

Depletion of circ_0057583 alleviated LPS-triggered brain microvascular endothelial endothelial cell injury through modulating miR-204-5p/NR4A1 axis.
Other information
Title:

Circ_0057583 facilitates brain microvascular endothelial cell injury through modulating miR-204-5p/NR4A1 axis.

Journal: Metab Brain Dis
Published: 2021/11/13
PubMed ID: 34767155