circRNA basic information
circBase ID: hsa_circ_0000215
Name: -
Synonym: Circ_0000215
Host Gene: hsa-miR-512-5p
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PIK3R1
Associated microRNA: hsa-miR-512-5p
Biological function: The functional experiments confirmed that knockdown of circ_0000215 impeded the growth and metastasis of NPC cells in vitro and in vivo
Molecular mechanism: circ_0000215 could also work as a molecular sponge to repress hsa-miR-512-5p expression. PIK3R1 was validated as a target gene of hsa-miR-512-5p, and circ_0000215 could increase the expression level of PIK3R1 in NPC cells via suppressing hsa-miR-512-5p
Survival: -
Supported No.:
 1
Description:

Circ_0000215 is overexpressed in NPC and exerts oncogenic effects in NPC through regulating miR-512-5p/PIK3R1 axis.
Other information
Title:

Circ_0000215 Exerts Oncogenic Function in Nasopharyngeal Carcinoma by Targeting miR-512-5p.

Journal: Front Cell Dev Biol
Published: 2021/11/13
PubMed ID: 34765599