circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: CircPVT1
Host Gene: hsa-miR-125b
 
 
 
Disease basic information
DO ID:
 9952
DO name: acute lymphoblastic leukemia
Disease details: acute lymphoblastic leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NF-kappaB signal pathway
Associated microRNA: hsa-miR-125b
Biological function: CircPVT1 over-expression promoted ALL cell proliferation and migration besides invading.
Molecular mechanism: CircPVT1 was able to enhance NF-kappaB signal pathways expression through reducing hsa-miR-125b
Survival: -
Supported No.:
 2
Description:

CircPVT2 can promote ALL cell proliferation and invading through miR-125b modulation of NF-kappaB, which would be one new potential target for ALL therapy.
Other information
Title:

Regulation Effects of Circular RNA CircPVT1 and miR-125b on NF-kappaB Signal Pathway in Childhood ALL.

Journal: Clin Lab
Published: 2021/11/11
PubMed ID: 34758237