circRNA basic information
circBase ID: -
Name: hsa_circ_USP7
Synonym: circUSP7
Host Gene: hsa-miR-934
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SHP2
Associated microRNA: hsa-miR-934
Biological function: -
Molecular mechanism: -
Survival: poor
Supported No.:
 1
Description:

Exosomal circUSP7 is predominantly secreted by NSCLC cells and contributes to immunosuppression by promoting CD8(+) T cell dysfunction in NSCLC. CircUSP7 induces resistance to anti-PD1 immunotherapy, providing a potential therapeutic strategy for NSCLC patients.
Other information
Title:

Cancer cell-derived exosomal circUSP7 induces CD8(+) T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC.

Journal: Mol Cancer
Published: 2021/11/11
PubMed ID: 34753486