circRNA basic information
circBase ID: hsa_circ_0037128
Name: -
Synonym: circ_0037128
Host Gene: hsa-miR-497-5p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: Diabetic nephropathy
Species: human
Species details: human
Sample type: cell line
Sample type details: HK-2 cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NFAT5
Associated microRNA: hsa-miR-497-5p
Biological function: Circ_0037128 inhibition bated HG-caused inhibition effect on cell proliferation and promotion effects on oxidative stress, inflammation and fibrosis in HK-2 cells.
Molecular mechanism: circ_0037128 sponged miR-497-5p to modulate NFAT5.
Survival: -
Supported No.:
 1
Description:

Circ_0037128 downregulation could mitigate HG-stimulated cell damage via regulating the miR-497-5p/NFAT5 axis in HK-2 cells_n vitro, providing a possible therapy target for DN.
Other information
Title:

Circular RNA_0037128 aggravates high glucose-induced damage in HK-2 cells via regulation of microRNA-497-5p/nuclear factor of activated T cells 5 axis.

Journal: Bioengineered
Published: 2021/11/11
PubMed ID: 34753398