circRNA basic information
circBase ID: hsa_circ_0043532
Name: -
Synonym: circ_0043532
Host Gene: hsa-miR-182
 
 
 
Disease basic information
DO ID:
 11612
DO name: polycystic ovary syndrome
Disease details: Polycystic ovary syndrome
Species: human
Species details: human
Sample type: cell line
Sample type details: PCOS granulosa cells (GCs) and KGN cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SGK3
Associated microRNA: hsa-miR-182
Biological function: Silencing of circ_0043532 suppressed cell proliferation and cell cycle process and promoted cell apoptosis in PCOS GCs and KGN cells.
Molecular mechanism: circ_0043532 was identified as a sponge of miR-182 and SGK3 was confirmed to be a target gene of miR-182.
Survival: -
Supported No.:
 2
Description:

Deficiency of circ_0043532 suppressed cell proliferation and induced cell cycle arrest and cell apoptosis in PCOS by modulation of miR-182/SGK3 axis.
Other information
Title:

Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome.

Journal: Reprod Biol Endocrinol
Published: 2021/11/7
PubMed ID: 34740363