circRNA basic information
circBase ID: -
Name: hsa_circ_ciRS7
Synonym: ciRS-7
Host Gene: hsa-miR-139-3p
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TAGLN
Associated microRNA: hsa-miR-139-3p
Biological function: Depletion of ciRS-7 significantly inhibited RCC cell proliferation, invasion, tumor growth and metastasis in vivo, while overexpression of ciRS-7 had the opposite effect
Molecular mechanism: ciRS-7 acts as a ceRNA for hsa-miR-139-3p to prevent TAGLN degradation and promoting RCC progression and metastasis via the PI3K/AKT signaling pathway
Survival: -
Supported No.:
 1
Description:

ciRS-7 acts as a tumor promoter by regulating the miR-139-3p/TAGLN axis and activating the PI3K/AKT signaling pathway to promote RCC progression and metastasis.
Other information
Title:

ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma.

Journal: Mol Cancer
Published: 2021/11/7
PubMed ID: 34740354