circRNA basic information
circBase ID: -
Name: hsa_circ_ERBB2
Synonym: circ-ERBB2
Host Gene: hsa-miR-136-5p, hsa-miR-198
 
 
 
Disease basic information
DO ID:
 0060079
DO name: Her2-receptor positive breast cancer
Disease details: HER2-positive breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TFAP2C
Associated microRNA: hsa-miR-136-5p, hsa-miR-198
Biological function: the interference with circ-ERBB2 repressed HER2-positive breast cancer cell proliferation, migration, invasion and accelerated cell apoptosis
Molecular mechanism: circ-ERBB2 acted as a competing endogenous RNA for hsa-miR-136-5p or hsa-miR-198 to relieve the repressive influence of hsa-miR-136-5p or hsa-miR-198 on its target transcription factor activator protein 2C (TFAP2C)
Survival: -
Supported No.:
 1
Description:

Circ-ERBB2 accelerated HER2-positive breast cancer progression through the circ-ERBB2/miR-136-5p/TFAP2C axis or the circ-ERBB2/miR-198/TFAP2C axis.
Other information
Title:

Circular RNA circ-ERBB2 promotes HER2-positive breast cancer progression and metastasis via sponging miR-136-5p and miR-198.

Journal: J Transl Med
Published: 2021/11/5
PubMed ID: 34732216