circRNA basic information
circBase ID: -
Name: hsa_circ_BNIP3L
Synonym: circ-BNIP3L
Host Gene: hsa-miR-370-3p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HK-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MYD88
Associated microRNA: hsa-miR-370-3p
Biological function: Silencing of circ-BNIP3L attenuated LPS-induced growth inhibition, inflammation, and oxidative stress in HK-2 cells.
Molecular mechanism: circ-BNIP3L competitively bound to miR-370-3p to up-regulate the expression of its target MYD88.
Survival: -
Supported No.:
 1
Description:

Circ-BNIP3L knockdown alleviated LPS-induced renal tubular epithelial cell injury by miR-370-3p/MYD88 axis, opening up a completely new avenue for the treatment of sepsis-associated AKI.
Other information
Title:

Circ-BNIP3L knockdown alleviates LPS-induced renal tubular epithelial cell injury during sepsis-associated acute kidney injury by miR-370-3p/MYD88 axis.

Journal: J Bioenerg Biomembr
Published: 2021/11/4
PubMed ID: 34731384