circRNA basic information
circBase ID: hsa_circ_0114427
Name: -
Synonym: circ_0114427
Host Gene: hsa-miR-495-3p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HK-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRAF6
Associated microRNA: hsa-miR-495-3p
Biological function: IL-1beta and TNF-¦Á were highly expressed in LPS-induced AKI cells. Functionally, circ_0114427 was a sponge of miR-495-3p, and circ_0114427 silence-mediated effects in LPS-induced HK-2 cells were partly ameliorated by the addition of miR-495-3p inhibitor. Moreover, TRAF6 was a target gene of miR-495-3p, and the inhibiting effect of miR-495-3p on cell apoptosis and inflammatory response was mitigated by TRAF6 overexpression.
Molecular mechanism: the circ_0114427/miR-495-3p/TRAF6 axis modulated cell apoptosis and inflammatory response via NF-¦ÊB/p65 signalling pathway in AKI.
Survival: -
Supported No.:
 1
Description:

Circ_0114427 regulates LPS-induced HK-2 cell injury by regulating miR-495-3p/TRAF6/NF-¦ÊB/p65 axis.
Other information
Title:

Circ_0114427 promotes LPS-induced septic acute kidney injury by modulating miR-495-3p/TRAF6 through the NF-kappaB pathway.

Journal: Autoimmunity
Published: 2021/11/4
PubMed ID: 34730059