circRNA basic information
circBase ID: hsa_circ_0001588
Name: -
Synonym: circ_0001588
Host Gene: hsa-miR-874
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human HCC cell lines (SK-Hep-1, Hep-3B, HepG2, BEL-7402, MHCC-LM3), control hepatic normal cell line (LO2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK4
Associated microRNA: hsa-miR-874
Biological function: knockdown of circ_0001588 resulted in repressed cell proliferation, migration, and invasion
Molecular mechanism: by targeting the hsa-miR-874/CDK4 signaling pathway
Survival: -
Supported No.:
 1
Description:

circ_0001588 acts as a ceRNA and promotes HCC progression by targeting the miR-874/CDK4 signaling pathway.
Other information
Title:

circ_0001588 Induces the Malignant Progression of Hepatocellular Carcinoma by Modulating miR-874/CDK4 Signaling.

Journal: J Immunol Res
Published: 2021/11/2
PubMed ID: 34722778