circRNA basic information
circBase ID: -
Name: hsa_circ_FAM114A2
Synonym: CircFAM114A2
Host Gene: hsa-miR-222-3p
 
 
 
Disease basic information
DO ID:
 4006
DO name: bladder urothelial carcinoma
Disease details: urothelial carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: urothelial carcinoma cell lines (SV-HUC, BIU87, TCC, T24, RT4, 5637, 253J, UMUC3, J82)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: P27
Associated microRNA: hsa-miR-222-3p
Biological function: CircFAM114A2 could inhibit cell proliferation and block more urothelial carcinoma cells in the G1 phase and then increase the sensitivity of urothelial carcinoma to cisplatin chemotherapy
Molecular mechanism: circFAM114A2 directly sponged hsa-miR-222-3p/hsa-miR-146a-5p and subsequently influenced the expressions of the downstream target genes P27/P21
Survival: better
Supported No.:
 2
Description:

CircFAM114A2 could inhibit progression and promote cisplatin sensitivity in urothelial carcinoma through novel circFAM114A2/miR-222-3p/P27 and circFAM114A2/miR-146a-5p/P21 pathways.
Other information
Title:

CircFAM114A2 Promotes Cisplatin Sensitivity via miR-222-3p/P27 and miR-146a-5p/P21 Cascades in Urothelial Carcinoma.

Journal: Front Oncol
Published: 2021/11/2
PubMed ID: 34722233