circRNA basic information
circBase ID: -
Name: hsa_circ_SOX13
Synonym: circSOX13
Host Gene: hsa-miR-3194-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human bronchial epithelial cell line (16HBE), parental NSCLC cell lines (PC9, SPC-A1, H1975, H1299, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MAPRE1
Associated microRNA: hsa-miR-3194-3p
Biological function: knocking down circSOX13 or overexpressing miR-3194-3p inhibited NSCLC proliferation, invasion and migration but promoted its apoptosis
Molecular mechanism: circSOX13 mediated MAPRE1 expression via competitively binding hsa-miR-3194-3p to exert its tumorigenic impact
Survival: -
Supported No.:
 1
Description:

circSOX13 and the microtubule-associated protein RP/EB family member 1 (MAPRE1) were signally up-regulated in NSCLC while miR-3194-3p was signally lowered.
Other information
Title:

Circular RNA SOX13 promotes malignant behavior and cisplatin resistance in non-small cell lung cancer through targeting microRNA-3194-3p/microtubule-associated protein RP/EB family member 1.

Journal: Bioengineered
Published: 2021/10/29
PubMed ID: 34709968