circRNA basic information
circBase ID: -
Name: hsa_circ_RNF220
Synonym: CircRNF220
Host Gene: hsa-miR-30a
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: MYSM1 and IER2
Associated microRNA: hsa-miR-30a
Biological function: circRNF220 knockdown specifically inhibited proliferation and promoted apoptosis in AML cell lines and primary cells
Molecular mechanism: circRNF220 may act as an endogenous sponge of hsa-miR-30a to sequester hsa-miR-30a and inhibit its activity, which increases the expression of its targets MYSM1 and IER2 and implicated in AML relapse
Survival: poor
Supported No.:
 2
Description:

we characterized the function of circRNF220 and found that circRNF220 knockdown specifically inhibited proliferation and promoted apoptosis in AML cell lines and primary cells. Mechanistically, circRNF220 may act as an endogenous sponge of miR-30a to sequester miR-30a and inhibit its activity, which increases the expression of its targets MYSM1 and IER2 and implicated in AML relapse.
Other information
Title:

CircRNF220, not its linear cognate gene RNF220, regulates cell growth and is associated with relapse in pediatric acute myeloid leukemia.

Journal: Mol Cancer
Published: 2021/10/28
PubMed ID: 34702297