circRNA basic information
circBase ID: -
Name: hsa_circ_GFRA1
Synonym: CircGFRA1
Host Gene: hsa-miR-1228
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: AIFM2
Associated microRNA: hsa-miR-1228
Biological function: Knockdown of circGFRA1 could attenuate HER-2-positive BC progression by inhibiting the proliferation, infiltration and migratory ability of HER-2-positive BC cells
Molecular mechanism: circGFRA1 could bind to hsa-miR-1228 and alleviate inhibitory activity of hsa-miR-1228 on targeted gene AIFM2
Survival: -
Supported No.:
 3
Description:

CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression.
Other information
Title:

CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression.

Journal: J Cell Mol Med
Published: 2021/10/21
PubMed ID: 34668628