circRNA basic information
circBase ID: -
Name: hsa_circ_GSK3B
Synonym: CircGSK3B
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: RORA
Associated microRNA: -
Biological function: inhibit the growth, invasion, and metastasis of GC cells both in vitro and in vivo
Molecular mechanism: circGSK3B directly interacted with EZH2, acting to suppress the binding of EZH2 and H3K27me3 to the RORA promoter, and leading to an elevation in RORA expression and ultimately the suppression of GC progression
Survival: -
Supported No.:
 1
Description:

CircGSK3B acts as a tumor suppressor, reducing EZH2 trans-inhibition and GC progression.
Other information
Title:

CircGSK3B promotes RORA expression and suppresses gastric cancer progression through the prevention of EZH2 trans-inhibition.

Journal: J Exp Clin Cancer Res
Published: 2021/10/21
PubMed ID: 34666800